Endocrine Abstracts

BackgroundFalse positive results are common in the screening of pheochromocytoma. Even in high risk patients with disorders related to multiple endocrine neoplasia it’s crucial to exclude possible interferences with analytical methods.Clinical caseA 69 year-old man was submitted to total thyroidectomy, due to a 11 mm hypoechogenic nodule suspicious of papillary carcinoma (FNA). Histology confirmed medull...

Introduction: Pharmacologically induced false positive results in urinary free cortisol levels (UFCL) have been ascribed to 11βHSD-2 inhibition or direct interference on HPLC. Few drugs have been implicated by mechanisms not yet confirmed.Case Reports: We report 3 patients with active pulmonary tuberculosis (TB) and very high UFCL, 2-6× above the upper limit of reference [mean levels 3411 μg/24 h (RR 167-827)]. The 2 males and the woman ag...

Introduction: Osteoporosis is a metabolic bone disease, characterized by reduction and changes in the bone mass quantity and quality, leading to an increased risk of fractures. It can be divided in primary (postmenopausal or senile), secondary and idiopathic. In the presence of osteoporotic fractures, particularly in men before the age of 65, it is essential to investigate the presence of secondary causes in order to establish an etiological therapy.Case...

Background: Denosumab (Dmab) is a human monoclonal antibody with an anti-reabsorptive bone effect, used in osteoporosis treatment. It is also suggested that Dmab may improve glucose tolerance through the reduction of hepatic insulin resistance. Some studies have suggested that insulin sensitivity and glycemia can influence bone metabolism.Aims: To evaluate the relationship between bone turnover markers (BTM) and insulin resistance and glycemia in fractur...

Introduction: Pituitary metastases account for approximately 1% of pituitary lesions, most frequently originating from lung or breast cancer. We describe a case of a pituitary metastasis from colon cancer, a rare origin.Case report: a 36 year-old male, previously healthy, came to the emergency department for new onset jaundice and fever. He also had headaches for the last 3 months, and for the last month diplopia, left palpebral ptosis and low libido. Ph...

Introduction: Autosomal dominant polycystic kidney disease (ADPKD) is an inherited kidney disease characterized by the development and growth of cysts causing a progressive kidney enlargement and the end-stage renal disease (ESRD). The incidence of brain aneurysms in patients with ADPKD is high thus screening is recommended. The association of pituitary incidentalomas and ADPKD is rarely described in the literature. All reported pituitary adenomas in patients with ADPKD were f...

Although it is well known that aplastic anemia and agranulocytosis are potential lethal adverse reactions of antithyroid treatment, we present a case of methimazole administration in a patient with bone marrow transplant for multiple myeloma, with favorable evolution. We present the case of a 43 y.o. male, known with Grave’s disease since 2010 (on ATS treatment for only 6 months), vitiligo, systemic sclerosis and type 1 diabetes, diagnosed with multiple mieloma Ig G Tipe,...

Background: The association between Graves’ disease and thymic hyperplasia is well documented in the literature. Despite that it remains largely unrecognized in routine clinical practice. The lack of familiarity of usually benign nature of thymic hyperplasia associated with Graves’ disease may result in an aggressive management course, along with associated risks.Case presentation: A previously healthy 32-year-old female was admitted to hospita...

Introdution: Pituitary apoplexy (PA) is a rare clinical syndrome caused by sudden hemorrhage or infarction of the pituitary gland. PA may be the form of presentation of a pituitary tumor or occur during follow-up of a previously diagnosed macroadenoma. A high suspicion índex is required to establish a timely diagnosis.Case report: A 54-year-old man was referred to Endocrinology department (04/2015) due to a pituitary macroadenoma. He reported sexual...

Gitelman’s Syndrome (GS) is a rare autosomal recessive salt-losing tubulopathy of young adults, characterized by secondary hyperaldosteronism, hypokalemia, hypomagnesemia, hypocalciuria and metabolic alkalosis. It is caused by mutations in SLC12A3 gene. Hypercalcemia due to hypocalciuria in these patients is extremely rare and requires further evaluation.A 25-year-old normotensive female was referred to Endocrinology clinic for evaluation o...